Escalation looms as ceasefire hopes fade: Israel's strikes on eastern Rafah mark a tense conclusion to failed talks.

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Residents and medics in Rafah, the biggest urban area in Gaza not yet overrun by Israeli ground forces, said an Israeli attack near a mosque killed at least three people and wounded others in the eastern Brazil neighbourhood.

Israeli forces bombarded areas of Rafah on Thursday, Palestinian residents said, as Prime Minister Benjamin Netanyahu dismissed U.S. President Joe Biden's threat to withhold weapons from Israel if it assaults the southern Gaza city.

A senior Israeli official said late on Thursday that the latest round of indirect negotiations in Cairo to halt hostilities in Gaza had ended and Israel would proceed with its operation in Rafah and other parts of the Gaza Strip as planned.

Israel has submitted to mediators its reservations about a Hamas proposal for a hostage release deal, the official said.

"If we must, we shall fight with our fingernails," Netanyahu said in a video statement. "But we have much more than our fingernails."

In Gaza, Palestinian militant groups Hamas and Islamic Jihad said their fighters fired anti-tank rockets and mortars at Israeli tanks massed on the eastern outskirts of the city.

Residents and medics in Rafah, the biggest urban area in Gaza not yet overrun by Israeli ground forces, said an Israeli attack near a mosque killed at least three people and wounded others in the eastern Brazil neighbourhood.

Video footage from the scene showed the minaret lying in the rubble and two bodies wrapped in blankets.

An Israeli air strike on two houses in the Sabra neighbourhood of Rafah killed at least 12 people including women and children.

Among the dead was a senior commander of the militant Al-Mujahedeen Brigades, and his family, and the family of another group leader, medics, relatives and the group said.

Israel says Hamas militants are hiding in Rafah, where the population has been swelled by hundreds of thousands of Gazans seeking refuge from the bombardments that have reduced most of the coastal enclave to ruins.

In the United States, the White House repeated its hope that Israel would not launch a full operation in Rafah, saying it did not believe that would advance Israel's aim of defeating Hamas.