A mother has died, while a father and two children are being treated in hospital after a blaze tore through a regional NSW home on Saturday morning.

A woman has died and two children have been rescued by firefighters following a house fire in the NSW Central West on Saturday morning.

The woman was retrieved from the building but was unable to be revived.

Emergency services were called to the family home on Pimpala Place, Orange about 5.45am on Saturday and arrived to find the house engulfed in flames.

A man escaped the blaze but suffered burns while trying to re-enter the home to rescue two children and a woman still trapped inside .

Local firefighters entered the building minutes after receiving Triple Zero calls and were able to free the children, who were suffering from smoke inhalation.

After the fire was extinguished, the mother was discovered in the front room of the house but couldn’t be revived and died at the scene.

The children were provided with emergency medical care by firefighters and police until paramedics arrived.

They were then transported to Orange Base hospital and later flown to Sydney for further treatment with their father.

A crime scene has been established, and inquiries were underway, but the cause of the blaze still hadn’t been determined late on Saturday afternoon, police said.

Firefighters from the investigation and research unit, police forensics officers and an ignitable liquid detection dog (K9,) were attending the scene to investigate where and how the fire started.

Acting superintendent Dane Philippe provided an update on Saturday morning.

He said Fire Rescue NSW received triple zero phone calls reporting the house fire at about 5.45am and crews arrived on the scene within six minutes.

While they were able to rescue the two children, he said the woman was “unable to be saved”.

Superintendent Adam Dewberry said he was unable to comment on the details around the fire but urged people to make sure they had working smoke alarms fitted in their homes that were less than ten years old.

“This is a tragedy that will be fully investigated,” he said.

Jason Hamling, the mayor of Orange, said news of the fire was “devastating” and while he was yet to receive personal details of the family members, it would be a tough time for the community.

“Anything that involves a family and fatal accident like this is devastating,” he said. “But Orange will wrap their arms around them.

“We’re such a heartwarming community, when they are back on their feet Orange will rally to help.”

Westmead children’s hospital in Sydney was still treating the two children on Saturday afternoon but didn’t have consent from the family to release their conditions.

The father was being treated at the nearby Westmead hospital.